Our research is aimed at identifying a genetic component to psychosis and the emphasis is on studying brain expressed genes that are located in the hominid specific Xq21.3/Yp11 region of homology (particularly ProtocadherinX/Y) although other X-Y homologous gene pairs are also under study (e.g. SYBL1-L). DNA sequence variation, epigenetic status, analysis of splice variation and mRNA/protein levels and distribution in specific brain regions are all under investigation.

Our DNA samples include over 300 families multiply affected by schizophrenia (collected in collaboration with L.E. Delisi, Department of Psychiatry, New York University), and monozygotic twin pairs discordant for schizophrenia. (Click here for a more theoretical description of the genetics research undertaken at POWIC.)

Hardware and software

The two genetics laboratories are based in the POWIC building and are well equipped with all standard equipment for molecular biology techniques including an ALF Express DNA Sequencer and four thermal cyclers (including two Mastercycler Gradient machines).